Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients


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Vitiligo is a chronic stigmatizing disease, already known for millennia, which mainly affects melanocytes from epidermis basal layer, leading to the development of hypochromic and achromic patches. Its estimated prevalence is 0. The involvement of genetic factors controlling susceptibility to vitiligo has been studied over the last decades, and results of previous studies present vitiligo as a complex, multifactorial and polygenic disease.

Keep up to date with the latest research about vitiligo and all things skin related with The most common sites for vitiligo are the hands and face, around body.

Radiation-induced hypopigmentation consistent vitiligo has been reported in a few case reports. We report herewith a case of vitiligo at the site of radiation delivery after a lag of several months in a patient with preexisting hypothyroidism without a previous or family history of vitiligo, and review the cases reported in the literature collectively.

Vitiligo is a disease characterized by depigmented macules in the skin that result from a melanocyte loss. Radiation-related melanocyte loss has been described in the literature and has been incriminated for the patches of vitiligo in the radiation port. After a discussion, patient was operated on with left modified radical mastectomy. Histopathologic examination of the tumor revealed a disease consistent with T2 and N2.

She had no metastases elsewhere M0.

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A novel immunotolerizing therapy for autoimmune vitiligo. Award Information. Agency: Award Start Date (Proposal Award Date): Award End Date.

Study record managers: refer to the Data Element Definitions if submitting registration or results information. The treatment of vitiligo includes both medical and surgical modalities, whose goal is to restore melanocytes to the depigmented skin so that the epidermis restores back to normal morphology and functions. Although medical treatment is the main stay of treatment, it is not effective in all and residual lesions need augmented surgical treatment later for further completion of repigmentation.

Now a day surgical modalities have become treatment of choice for stable vitiligo not responding to medical treatment although there are numerous sites which do not respond that well to surgical procedure as well. The investigators ought to compare the efficacy of 3 well established surgical methods i. Mini Punch Grafting vs Suction Blister Epidermal Grafting vs Non Cultured Epidermal cell Suspension on stable vitiligo patches localized to acral areas and bony prominences like elbows, knees and ankles.

Out of all the vitiligo patches in a given participant, 3 different patches on acral and bony areas will be chosen and participants will be treated with 3 different methods. The punched out chambers are spaced at a gap of less than 5 mm preferably 2 – 2. The donor area is either upper lateral portion of thigh or gluteal region. Grafts are placed directly from donor to the recipient area. Care is taken, so that graft edges are not folded, the tissue is not crushed or placed upside down.

Hemostasis is achieved by pressing a saline soaked gauze piece over the area.

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DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Vitiligo is an acquired depigmenting disorder of the skin, in which pigment cells melanocytes are lost.

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Vitiligo is one of the most common dermatological disorders, appearing as one or more white macules or patches and affecting up to two percent of the population worldwide. The undesirable aesthetic properties of vitiligo, especially facial, may result in significant negative psychosocial effects, particularly a rate of depression twice that of the general population. While there is no cure, there are several treatment options, notably depigmentation in severe cases. Monobenzone is the most potent depigmenting agent.

However, its use is limited due to the permanent and potent nature of the drug. This case presents an example of when timely and aggressive treatment with monobenzone is warranted, demonstrating excellent clinical response, which resulted in a significant increase in the quality of life in a patient with severe vitiligo.

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DOI: Introduction: Vitiligo is an acquired skin disease characterized by loss of functional melanocytes from the epidermis. Despite the several factors studied the pathogenesis of vitiligo remains unclear. Vitiligo could be associated with low vitamin D levels and high level of interleukin Objective: The aim of this study was to evaluate serum 25 OH D levels, interleukinserumlevels and correlation between them in vitiligo patients in comparison of normal controls.

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But this isn’t the case for people who have a condition called vitiligo. Vitiligo is a loss of skin pigment that causes white spots or patches to appear on the skin. No one knows exactly why this happens, but it affects people of all races, many of them kids and teens. Because vitiligo affects a person’s appearance, it can be upsetting.

But it isn’t medically dangerous. It’s not a form of skin cancer. It’s not an infection like MRSA. And it’s definitely not contagious, so you can’t catch it from someone else. In fact, most of the people who have vitiligo are every bit as healthy as everyone else. To explain vitiligo, it helps to know a bit about how skin gets its color in the first place. Skin color is determined by cells called melanocytes. They produce a pigment called melanin , which gives skin its color and helps protect it from the sun.

Dark-skinned people have cells that naturally produce a lot of melanin, while light-skinned people produce much less. Sometimes, the skin suddenly stops producing melanin.

Would you date a guy with vitiligo?

Its one of those subjects that creates a lot of discussion, divided opinion and for some, can be quite sensitive as ultimately it means trusting someone and feeling comfortable about showing our skin in front of a potential partner. Dating can be difficult in general but what does dating look like when you have vitiligo? For some, especially if they have vitiligo extensively, it can overshadow the entire experience, altering what we to choose to wear and possibly, how we come across on the actual date.

Aside from simply feeling confident ahead of a date, there is also the added pressure of making sure your makeup is looking flawless ladies! The inside actually counts too!

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Correlation between Vitamin D and Interleukin – 21 in Patients with Vitiligo

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Suction Blister Grafting and Non-Cutured Epidermal Cell Suspension on Resistant Sites in Stable Vitiligo. Actual Study Start Date: July 1.

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